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题名	Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection
作者	Tang, X.1,2 ; Zhang, S.3; Peng, Q.4; Ling, L.5; Shi, H.1; Liu, Y.1; Cheng, L.1; Xu, L.4; Cheng, L.6; Chakrabarti, L.A.7; Chen, Z.1,5; Wang, H.4; Zhang, Z.1,2,8,9
通讯作者	Zhang, Z.
发表日期	2020
DOI	10.1126/sciadv.aaz0374
发表期刊	Science Advances 影响因子和分区
ISSN	23752548
卷号	6 期号:8
摘要	Mucosal-associated invariant T (MAIT) cells in HIV-1–infected individuals are functionally impaired by poorly understood mechanisms. Single-cell transcriptional and surface protein analyses revealed that peripheral MAIT cells from HIV-1–infected subjects were highly activated with the up-regulation of interferon (IFN)–stimulated genes as compared to healthy individuals. Sustained IFN-α treatment suppressed MAIT cell responses to Escherichia coli by triggering high-level interleukin-10 (IL-10) production by monocytes, which subsequently inhibited the secretion of IL-12, a crucial costimulatory cytokine for MAIT cell activation. Blocking IFN-α or IL-10 receptors prevented MAIT cell dysfunction induced by HIV-1 exposure in vitro. Moreover, blocking the IL-10 receptor significantly improved anti–Mycobacterium tuberculosis responses of MAIT cells from HIV-1–infected patients. Our findings demonstrate the central role of the IFN-I/IL-10 axis in MAIT cell dysfunction during HIV-1 infection, which has implications for the development of anti–IFN-I/IL-10 strategies against bacterial coinfections in HIV-1–infected patients. Copyright © 2020 The Authors.
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
重要成果	NI期刊 ; NI论文
学校署名	通讯
资助项目	National Basic Research Program of China (973 Program)[2015CB554300] ; National Major Science and Technology Projects of China[2017ZX10201101001007] ; National Natural Science Foundation of China[81701636] ; National Major Science and Technology Projects of China[JCYJ20170412151650600] ; National Major Science and Technology Projects of China[JCYJ20170412151722110] ; National Basic Research Program of China (973 Program)[SZSM201512029]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000514842000033
出版者	American Association for the Advancement of Science
EI入藏号	20200908211176
EI主题词	Escherichia Coli ; Transcription
EI分类号	Biology:461.9
来源库	Web of Science
引用统计	被引频次[WOS]：26
成果类型	期刊论文
条目标识符	//www.snoollab.com/handle/2SGJ60CL/104542
专题	医学院第二附属医院
作者单位	1.Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province; 518112, China 2.Second Affiliated Hospital, School of Medicine, South University of Science and Technology, Shenzhen; 518100, China 3.Shanghai Public Health Clinical Center, Institute of Biomedical Sciences, Fudan University, Shanghai; 201508, China 4.Depart-ment of Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen; 518112, China 5.AIDS Institute and Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong 6.Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill; NC, United States 7.Institut Pasteur, Groupe Contrôle des Infections Virales Chroniques, Unité Virus et Immunité, Paris Cedex 15; 75724, France 8.Guangdong Key Lab of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen; 518112, China 9.Key Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou; 511436, China
第一作者单位	医学院; 第二附属医院
通讯作者单位	医学院; 第二附属医院
推荐引用方式 GB/T 7714	Tang, X.,Zhang, S.,Peng, Q.,et al. Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection[J]. Science Advances,2020,6(8).
APA	Tang, X..,Zhang, S..,Peng, Q..,Ling, L..,Shi, H..,...&Zhang, Z..(2020).Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection.Science Advances,6(8).
MLA	Tang, X.,et al."Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection".Science Advances 6.8(2020).